Article
Apoptosis genes and autoimmunity.
Current opinion in immunology - 1 Dec 2000
Vaux D L, Flavell R A
Abstract excerpt
To try to understand autoimmunity, attention has often fallen on the process of cell death. After all, apoptosis is used during selection of immunocytes, cells in the target organs end up dying and mutations to cell death genes have been found in some autoimmune diseases. Furthermore, some autoimmune-prone mice fail to develop disease when certain cell death genes are deleted, and transgenic mice expressing other...
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