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Article

Deletions in the N-terminal segment of the plasma membrane Ca(2+) pump impair the expression of a correctly folded functional enzyme.

Biochemistry - 5 Dec 2000

Adamo H P, Grimaldi M E, García Arguinzonis M I

Abstract excerpt

Mutant cDNAs encoding h4 plasma membrane Ca(2+) pumps with deletions in the N-terminal segment have been constructed and expressed in COS cells. As judged by immunoblotting, each construct was expressed at a high level similar to that of the wild-type enzyme. The removal of the first six amino acids had no effect on the Ca(2+) transport activity, but deletions in the segment 15-75 reduced the activity to...

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PMID: 11101305
DOI: 10.1021/bi001222c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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