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Article

Male Infertility Caused by a de Novo Partial Deletion of the DAZ Cluster on the Y Chromosome1

1 Nov 2000

Abstract excerpt

Deletions in distal Yq interval 6 represent the cause of 10-15% of idiopathic severe male infertility and map to a region defined AZFc (azoospermia factor c). The testis-specific gene DAZ is considered a major AZFc candidate, and its deletion has been associated with a severe disruption in spermatogenesis. However, DAZ is actually a multicopy gene family consisting of seven clustered copies spanning about 1...

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PMID: 11095434
DOI: 10.1210/jcem.85.11.6929

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Male Infertility Caused by a de Novo Partial Deletion of the DAZ Cluster on the Y Chromosome1PMID 11095434Read ↗

High frequency of DAZ1/DAZ2 gene deletions in patients with severe oligozoospermiaSemantic proximity Read ↗

Association of partial AZFc region deletions with spermatogenic impairment and male infertility.Semantic proximity Read ↗

Y-chromosome AZFc structural architecture and relationship to male fertility.Semantic proximity Read ↗

AZF and DAZ gene copy-specific deletion analysis in maturation arrest and Sertoli cell-only syndromeSemantic proximity Read ↗

Partial deletions are associated with an increased risk of complete deletion in AZFc: a new insight into the role of partial AZFc deletions in male infertilitySemantic proximity Read ↗

Analysis of the DAZ gene family in cryptorchidism and idiopathic male infertility.Semantic proximity Read ↗

Additional genomic duplications in AZFc underlie the b2/b3 deletion-associated risk of spermatogenic impairment in Han Chinese populationSemantic proximity Read ↗

Sequence family variant loss from the AZFc interval of the human Y chromosome, but not gene copy loss, is strongly associated with male infertility.Semantic proximity Read ↗

Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertilitySemantic proximity Read ↗

Association of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population.Semantic proximity Read ↗

Gene copy number alterations in the azoospermia-associated AZFc region and their effect on spermatogenic impairmentSemantic proximity Read ↗

Azoospermic men with deletion of the DAZ gene cluster are capable of completing spermatogenesis: fertilization, normal embryonic development and pregnancy occur when retrieved testicular spermatozoa are used for intracytoplasmic sperm injectionSemantic proximity Read ↗

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