Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovery of allelic variants of HOXA1 and HOXB1: genetic susceptibility to autism spectrum disorders.

Teratology - 1 Dec 2000

Ingram J L, Stodgell C J, Hyman S L, Figlewicz D A, Weitkamp L R, Rodier P M

Abstract excerpt

BACKGROUND: Family studies have demonstrated that the autism spectrum disorders (ASDs) have a major genetic etiologic component, but expression and penetrance of the phenotype are variable. Mice with null mutations of Hoxa1 or Hoxb1, two genes critical to hindbrain development, have phenotypic features frequently observed in autism, but no naturally occurring variants of either gene have been identified in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abnormalities, Multiple
Share to Autistic Disorder
Share to Brain Stem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comorbidity

Share to Embryonic and Fetal Development

Share to Genes, Homeobox

Share to Intellectual Disability

Share to New York

Source

Identifiers

PMID: 11091361
DOI: 10.1002/1096-9926(200012)62:6<393::AID-TERA6>3.0.CO;2-V

Genes

HOXA1
HOXB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovery of allelic variants of HOXA1 and HOXB1: genetic susceptibility to autism spectrum disorders.PMID 11091361Read ↗

An integrated meta-analysis of two variants in HOXA1/HOXB1 and their effect on the risk of autism spectrum disorders.Semantic proximity Read ↗

No association between allelic variants of HOXA1/HOXB1 and autism.Semantic proximity Read ↗

Lack of association between HoxA1 and HoxB1 gene variants and autism in 110 multiplex families.Semantic proximity Read ↗

Loss of ASH1L in developing brains causes autistic-like behaviors in a mouse modelSemantic proximity Read ↗

No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network.Semantic proximity Read ↗

HOXB1 founder mutation in humans recapitulates the phenotype of Hoxb1-/- mice.Semantic proximity Read ↗

The clinical spectrum of homozygous HOXA1 mutations.Semantic proximity Read ↗

Association between the HOXA1 A218G polymorphism and increased head circumference in patients with autism.Semantic proximity Read ↗

HOXA1 A218G polymorphism is associated with smaller cerebellar volume in healthy humans.Semantic proximity Read ↗

Allelic variation within the putative autism spectrum disorder risk gene homeobox A1 and cerebellar maturation in typically developing children and adolescents.Semantic proximity Read ↗

Beckwith Weidemann syndrome: a behavioral phenotype-genotype study.Semantic proximity Read ↗

The HOXA1 A218G polymorphism and autism: lack of association in white and black patients from the South Carolina Autism Project.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.