Article
Development and characterization of annexin V mutants with endogenous chelation sites for (99m)Tc.
Bioconjugate chemistry - 1 Jan 2000
Tait J F, Brown D S, Gibson D F, Blankenberg F G, Strauss H W
Abstract excerpt
[(99m)Tc]Annexin V can be used to image organs undergoing cell death during cancer chemotherapy and organ transplant rejection. To simplify the preparation and labeling of annexin V for nuclear-medicine studies, we have investigated the addition of peptide sequences that will directly form endogenous chelation sites for (99m)Tc. Three mutant molecules of annexin V, called annexin V-116, -117, and -118, were...
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