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Article

Auger electron radioimmunotherapeutic agent specific for the CD123+/CD131- phenotype of the leukemia stem cell population.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Sept 2011

Leyton Jeffrey Victor, Hu Meiduo, Gao Catherine, Turner Patricia V, Dick John E, Minden Mark, Reilly Raymond M

Abstract excerpt

UNLABELLED: Our aim was to construct and characterize (111)In-nuclear translocation sequence (NLS)-7G3, an Auger electron-emitting radioimmunotherapeutic agent that preferentially recognizes the expression of CD123 (interleukin-3 receptor [IL-3R] α-subchain) in the absence of CD131 (IL-3R β-subchain) displayed by leukemia stem cells. METHODS: Monoclonal antibody 7G3 was modified with 13-mer peptides...

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Identifiers

PMID: 21816968
DOI: 10.2967/jnumed.111.087668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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