Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA fragmentation, gliosis and histological hallmarks of Alzheimer's disease.

Acta neuropathologica - 1 Dec 2000

Overmyer M, Kraszpulski M, Helisalmi S, Soininen H, Alafuzoff I

Abstract excerpt

The extent of DNA fragmentation analysed using the TUNEL technique was evaluated in post-mortem human brain tissue. Twenty-four patients with clinical and histopathological diagnosis of Alzheimer's disease (AD) and a short post-mortem delay were analysed. We report an increase in the count of TUNEL-labelled cells as the pathology of AD intensifies. Our results point out a significant correlation between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to DNA Fragmentation
Share to Gliosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Nick-End Labeling

Share to Microglia

Share to Nerve Degeneration

Share to Neurofibrillary Tangles

Share to Plaque, Amyloid

Source

Identifiers

PMID: 11078220
DOI: 10.1007/s004010000228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA fragmentation, gliosis and histological hallmarks of Alzheimer's disease.PMID 11078220Read ↗

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situSemantic proximity Read ↗

Repair of Oxidative DNA Damage, Cell-Cycle Regulation and Neuronal Death May Influence the Clinical Manifestation of Alzheimer’s DiseaseSemantic proximity Read ↗

Alzheimer DiseaseSemantic proximity Read ↗

Cell death mechanisms in neurodegenerationSemantic proximity Read ↗

DNA damage and apoptosis in Alzheimer's disease: colocalization with c- Jun immunoreactivity, relationship to brain area, and effect of postmortem delaySemantic proximity Read ↗

DNA strand breaks in Alzheimer's diseaseSemantic proximity Read ↗

Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNELSemantic proximity Read ↗

DNA damage and senescence in the aging and Alzheimer’s disease cortex are not uniformly distributedSemantic proximity Read ↗

Immunohistochemical evidence for apoptosis in Alzheimerʼs diseaseSemantic proximity Read ↗

Increased Susceptibility to Oxidative Death of Lymphocytes from Alzheimer Patients Correlates with Dementia SeveritySemantic proximity Read ↗

The interaction between aging and DNA damage influences the accumulation of APP in Alzheimer’s diseaseSemantic proximity Read ↗

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.