Early lateral transfer of genes encoding malic enzyme, acetyl‐CoA synthetase and alcohol dehydrogenases from anaerobic prokaryotes to Entamoeba histolytica

Abstract excerpt

The fermentation enzymes, which enable the microaerophilic protist Entamoeba histolytica to parasitize the colonic lumen and tissue abscesses, closely resemble homologues in anaerobic prokaryotes. Here, genes encoding malic enzyme and acetyl-CoA synthetase (nucleoside diphosphate forming) were cloned from E. histolytica, and their evolutionary origins, as well as those encoding two alcohol dehydrogenases (ADHE...

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