Article
The HLA-DRB4 gene is present in half of the Spanish HLA-DQ2-negative celiac patients.
Immunogenetics - 1 Oct 2000
Garrote J A, Arranz E, Blanco-Quirós A
Abstract excerpt
We studied nine consecutive DQ2-negative celiacs [from a group of 186 consecutive celiac disease (CD) patients] for the presence of the HLA-DQB1, DRB1, and DRBx alleles. HLA-DR53 was present in only 5 out of 9 (55%) of DQ2-negative patients. DRB4 (DR53) positivity -39% of chromosomes--among Spanish DQ2-negative CD patients is due to both DR4- and DR7-positive cases. Spanish DQ2-positive patients show a high...
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