Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Circadian organization of thymidylate synthase activity in normal tissues: A possible basis for 5-fluorouracil chronotherapeutic advantage

1 Jan 2000

Abstract excerpt

Fluoropyrimidines induce cytotoxicity, in part, by inhibiting the proliferation-coordinated enzyme thymidylate synthase (TS), which is essential for DNA synthesis. Tumor TS levels are clinically predictive of post-surgical tumor recurrence and of response to fluoropyrimidine chemotherapy. Fluoropyrimidine drug toxicity and efficacy each vary reproducibly in humans and animals, depending upon their circadian...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Treatment and Pharmacology
Share to Chemotherapy-induced cardiotoxicity and mitigation
Share to Colorectal Cancer Treatments and Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11054680
DOI: 10.1002/1097-0215(20001101)88:3<479::aid-ijc23>3.0.co;2-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Circadian organization of thymidylate synthase activity in normal tissues: A possible basis for 5-fluorouracil chronotherapeutic advantagePMID 11054680Read ↗

The Relationship between Circadian Rhythm and Cancer DiseaseSemantic proximity Read ↗

Thymidine kinase 1 through the ages: a comprehensive reviewSemantic proximity Read ↗

Circadian clocks in health and disease: Dissecting the roles of the biological pacemaker in cancerSemantic proximity Read ↗

The Cancer Clock Is (Not) Ticking: Links between Circadian Rhythms and CancerSemantic proximity Read ↗

Cancer Clocks Out for Lunch: Disruption of Circadian Rhythm and Metabolic Oscillation in CancerSemantic proximity Read ↗

Circadian Timing in Cancer TreatmentsSemantic proximity Read ↗

Elevated Levels of Thymidylate Synthase Linked to Neoplastic Transformation of Mammalian CellsSemantic proximity Read ↗

Rhythms in Human Gastrointestinal Mucosa and SkinSemantic proximity Read ↗

Circadian Rhythm Disruption in Cancer BiologySemantic proximity Read ↗

The role of the circadian clock in cancer hallmark acquisition and immune-based cancer therapeuticsSemantic proximity Read ↗

Circadian clock and cell cycle: Cancer and chronotherapy.Semantic proximity Read ↗

The circadian clock and tumor suppression by mammalian period genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.