Article
Evolutionary conservation of redundancy between a diverged pair of forkhead transcription factor homologues.
Development (Cambridge, England) - 1 Nov 2000
Molin L, Mounsey A, Aslam S, Bauer P, Young J, James M, Sharma-Oates A, Hope I A
Abstract excerpt
The Caenorhabditis elegans gene pes-1 encodes a transcription factor of the forkhead family and is expressed in specific cells of the early embryo. Despite these observations suggesting pes-1 to have an important regulatory role in embryogenesis, inactivation of pes-1 caused no apparent phenotype. This lack of phenotype is a consequence of genetic redundancy. Whereas a weak, transitory effect was observed upon...
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