Article
Association of Peutz-Jeghers-like mucocutaneous pigmentation with breast and gynecologic carcinomas in women.
Medicine - 1 Sept 2000
Boardman L A, Pittelkow M R, Couch F J, Schaid D J, McDonnell S K, Burgart L J, Ahlquist D A, Carney J A, Schwartz D I, Thibodeau S N, Hartmann L C
Abstract excerpt
Most reports describe an increased risk of malignancy in Peutz-Jeghers syndrome (PJS). We identified individuals with PJS-like pigmentation but no polyposis, designated as isolated mucocutaneous melanotic pigmentation (IMMP), and 1) characterized their clinical features, 2) assessed them for cancer events, and 3) screened a sample of these subjects for mutations in LKB1, a gene responsible for a portion of PJS...
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