Article
Adenoviral vector-mediated rescue of the OMP-null phenotype in vivo.
Nature neuroscience - 1 Nov 2000
Ivic L, Pyrski M M, Margolis J W, Richards L J, Firestein S, Margolis F L
Abstract excerpt
The use of gene deletion by homologous recombination to determine gene or protein function has wide application in vertebrate neurobiology. An ideal complement to gene deletion would be subsequent gene replacement to demonstrate re-acquisition of function. Here we used an adenoviral vector to replace the olfactory marker protein (OMP) gene in olfactory receptor neurons of adult OMP-null mice and demonstrated the...
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