Article
Greater diversity of HIV-1 quasispecies in HIV-infected individuals with active tuberculosis.
Journal of acquired immune deficiency syndromes (1999) - 15 Aug 2000
Collins K R, Mayanja-Kizza H, Sullivan B A, Quiñones-Mateu M E, Toossi Z, Arts E J
Abstract excerpt
OBJECTIVE: A continual increase in intrapatient HIV-1 heterogeneity is thought to contribute to evasion of host immune response and eventual progression to AIDS. Tuberculosis (TB) is diagnosed both early and late during the course of HIV-1 disease and may increase diversity of HIV-1 quasispecies by activating the HIV-1 immune response and increasing HIV-1 replication. We examined whether HIV-1 heterogeneity is...
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