Article
Degradation of bradykinin by peritoneal and alveolar macrophages of the guinea pig.
Peptides - 1 Aug 2000
Vietinghoff G, Paegelow I
Abstract excerpt
Peptidase inhibitors and identification of the peptide fragments were used for the characterization of the bradykinin metabolism by alveolar and peritoneal macrophages. Both cell types show differences in the rate of inactivation and in the quantity of the metabolites generated. BK(1-5), BK(1-8), and BK(1-7) are the predominant direct metabolites. Metalloendopeptidase 24.15, carboxypeptidase M, and an...
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