Cellular responses to sodium butyrate exhibit the dominance of one parental phenotype in somatic cell hybrids.

doi:10.1006/mcbr.2000.0235

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Article

Cellular responses to sodium butyrate exhibit the dominance of one parental phenotype in somatic cell hybrids.

Molecular cell biology research communications : MCBRC - 1 Jun 2000

Cox G S

Abstract excerpt

The glycoprotein hormone alpha-subunit (GPHalpha) gene is inducible by sodium butyrate (NaBtr) in nontrophoblastic tumor cell lines such as HeLa (cervical carcinoma) but not in trophoblastic tumor cell lines such as JEG-3 (choriocarcinoma). The studies summarized in this report examined the ability of NaBtr to induce GPHalpha expression in somatic cell hybrids between HeLa SR3(hyg) and JEG-3(neo). The hybrid...

Topics

Butyrates
Cell Division
Choriocarcinoma
Chorionic Gonadotropin
Cycloheximide
DNA
DNA-Binding Proteins
Drug Resistance
Enhancer Elements, Genetic
Female
Gene Expression Regulation, Neoplastic
Genes, Dominant
Gentamicins
Glycoprotein Hormones, alpha Subunit

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Identifiers

PMID: 11032754
DOI: 10.1006/mcbr.2000.0235

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Humans

Hybrid Cells

Hygromycin B

Nuclear Proteins