Article
A randomized, placebo-controlled trial of granulocyte-macrophage colony-stimulating factor and nucleoside analogue therapy in AIDS.
The Journal of infectious diseases - 1 Nov 2000
Brites C, Gilbert M J, Pedral-Sampaio D, Bahia F, Pedroso C, Alcantara A P, Sasaki M D, Matos J, Renjifo B, Essex M, Whitmore J B, Agosti J M, Badaro R
Abstract excerpt
Preliminary preclinical and clinical data suggest that granulocyte-macrophage colony-stimulating factor (GM-CSF) may decrease viral replication. Therefore, 105 individuals with AIDS who were receiving nucleoside analogue therapy were enrolled in a placebo-controlled, double-blind study and were randomized to receive either 125 microgram/m(2) of yeast-derived, GM-CSF (sargramostim) or placebo subcutaneously twice...
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