Article
Mouse T-cell antigen rt6.1 has thiol-dependent NAD glycohydrolase activity.
Journal of biochemistry - 1 Oct 2000
Hara N, Terashima M, Shimoyama M, Tsuchiya M
Abstract excerpt
Mouse Rt6.1 and Rt6.2, homologues of rat T-cell RT6 antigens, catalyze arginine-specific ADP-ribosylation. Without an added ADP-ribose acceptor, Rt6.2 shows NAD glycohydrolase (NADase) activity. However, Rt6.1 has been reported to be primarily an ADP-ribosyltransferase, but not an NADase. In the present study, we obtained evidence that recombinant Rt6.1 catalyzes NAD glycohydrolysis but only in the presence of...
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