Mouse T-cell antigen rt6.1 has thiol-dependent NAD glycohydrolase activity.

doi:10.1093/oxfordjournals.jbchem.a022792

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Article

Mouse T-cell antigen rt6.1 has thiol-dependent NAD glycohydrolase activity.

Journal of biochemistry - 1 Oct 2000

Hara N, Terashima M, Shimoyama M, Tsuchiya M

Abstract excerpt

Mouse Rt6.1 and Rt6.2, homologues of rat T-cell RT6 antigens, catalyze arginine-specific ADP-ribosylation. Without an added ADP-ribose acceptor, Rt6.2 shows NAD glycohydrolase (NADase) activity. However, Rt6.1 has been reported to be primarily an ADP-ribosyltransferase, but not an NADase. In the present study, we obtained evidence that recombinant Rt6.1 catalyzes NAD glycohydrolysis but only in the presence of...

Topics

ADP Ribose Transferases
Adenosine Diphosphate Ribose
Animals
Antigens, Differentiation, T-Lymphocyte
COS Cells
Cysteine
Dithiothreitol
Escherichia coli
Ethylmaleimide
Histocompatibility Antigens
Hydrolysis
Kinetics
Macrophages, Peritoneal
Membrane Glycoproteins
Mice
Mice, Inbred BALB C
Mutation
NAD

Source

Open in PubMed

Identifiers

PMID: 11011142
DOI: 10.1093/oxfordjournals.jbchem.a022792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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