Article
A first trial of retrospective collaboration for positional cloning in complex inheritance: assay of the cytokine region on chromosome 5 by the consortium on asthma genetics (COAG).
Proceedings of the National Academy of Sciences of the United States of America - 26 Sept 2000
Lonjou C, Barnes K, Chen H, Cookson W O, Deichmann K A, Hall I P, Holloway J W, Laitinen T, Palmer L J, Wjst M, Morton N E
Abstract excerpt
The central problem of complex inheritance is to map oligogenes for disease susceptibility, integrating linkage and association over samples that differ in several ways. Combination of evidence over multiple samples with 1,037 families supports loci contributing to asthma susceptibility in the cytokine region on 5q [maximum logarithm of odds (lod) = 2.61 near IL-4], but no evidence for atopy. The principal...
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