Fixation of clonal lineages under Muller's ratchet.

Abstract excerpt

For clonal lineages of finite size that differ in their deleterious mutational effects, the probability of fixation is investigated by mathematical theory and Monte Carlo simulations. If these fitness effects are sufficiently small in one or both lineages, then the lineage with the less deleterious effects will become fixed with high probability. If, however, in both lineages the deleterious effects are larger...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computer Simulation
• Share to Evolution, Molecular
• Share to Models, Genetic