TP53 mutations and MDM2 gene amplification in squamous-cell carcinomas of the esophagus in south Thailand.

doi:10.1002/1097-0215(20001015)88:2<223::aid-ijc12>3.0.co;2-g

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TP53 mutations and MDM2 gene amplification in squamous-cell carcinomas of the esophagus in south Thailand.

International journal of cancer - 15 Oct 2000

Tanière P, Martel-Planche G, Puttawibul P, Casson A, Montesano R, Chanvitan A, Hainaut P

Abstract excerpt

Squamous-cell carcinoma of the esophagus (SCCE) shows geographic variations in incidence that are thought to reflect the etiological involvement of environmental or dietary risk factors. Mutations of TP53 are frequent in SCCE, and there is evidence that both the frequency and type of these mutations may differ from one geographic area to the other. Although SCCE is relatively rare in most parts of Thailand, the...

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TP53 mutations and MDM2 gene amplification in squamous-cell carcinomas of the esophagus in south Thailand.

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