Article
Toxin Gene Expression by Shiga Toxin-Producing <i>Escherichia coli</i>: the Role of Antibiotics and the Bacterial SOS Response
1 Oct 2000
Abstract excerpt
Toxin synthesis by Shiga toxin-producing Escherichia coli (STEC) appears to be coregulated through induction of the integrated bacteriophage that encodes the toxin gene. Phage production is linked to induction of the bacterial SOS response, a ubiquitous response to DNA damage. SOS-inducing antimicrobial agents, particularly the quinolones, trimethoprim, and furazolidone, were shown to induce toxin gene expression...
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