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Cumulative effect of prophage burden on Shiga toxin production in Escherichia coli

18 Nov 2011

Abstract excerpt

Shigatoxigenic Escherichia coli (STEC) such as E. coli O157 are significant human pathogens, capable of producing severe, systemic disease outcomes. The more serious symptoms associated with STEC infection are primarily the result of Shiga toxin (Stx) production, directed by converting Stx bacteriophages. During phage-mediated replication and host cell lysis, the toxins are released en masse from the bacterial...

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PMID: 22096150
DOI: 10.1099/mic.0.054981-0

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