The human beta-myosin heavy chain gene: sequence diversity and functional characteristics of the protein.

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Article

The human beta-myosin heavy chain gene: sequence diversity and functional characteristics of the protein.

Journal of cellular biochemistry - 14 Sept 2000

Wendel B, Reinhard R, Wachtendorf U, Zacharzowsky U B, Osterziel K J, Schulte H D, Haase H, Hoehe M R, Morano I

Abstract excerpt

The beta-myosin heavy chain gene (MYH7) encodes the motor protein that drives myocardial contraction. It has been proven to be a disease gene for hypertrophic cardiomyopathy (HCM). We analyzed the DNA sequence variation of MYH7 (about 16 kb) of eight individuals: six patients with HCM and two healthy controls. The overall DNA sequence identity was up to 97.2% compared to Jaenicke and coworkers (Jaenicke et al....

Topics

Base Sequence
Cardiomyopathy, Hypertrophic
Case-Control Studies
DNA
Genetic Variation
Humans
In Vitro Techniques
Kinetics
Myocardial Contraction
Myosin Heavy Chains

Source

Open in PubMed

Identifiers

PMID: 10996847

Genes

MYH7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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