Article
A heterozygous frameshift mutation in the Fanconi anemia C gene in familial T-ALL and secondary malignancy.
Klinische Padiatrie - 1 Jan 2000
Rischewski J R, Clausen H, Leber V, Niemeyer C, Ritter J, Schindler D, Schneppenheim R
Abstract excerpt
BACKGROUND: Patients with Fanconi Anemia (FANC) have a well documented increased risk to develop malignancies, especially Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS). The risk for heterozygous individuals is not clear, epidemiological data are inconsistent. If the risk for heterozygous individuals to develop malignancies was increased, they should be found in groups of patients with AML or MDS...
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