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Article

Role of Vif in human immunodeficiency virus type 1 reverse transcription

1 Dec 1996

Abstract excerpt

The Vif protein of human immunodeficiency virus type 1 (HIV-1) is important for virion infectivity. Previous studies have shown that vif mutant HIV-1 virions are defective in their ability to synthesize proviral DNA in vivo. Here, we examine the role of Vif in viral DNA synthesis in the endogenous reverse transcriptase (RT) reaction, an in vitro assay in which virions synthesize viral DNA by using endogenous...

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PMID: 8970997
DOI: 10.1128/jvi.70.12.8701-8709.1996

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