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Article

Role of HFE gene mutations in liver diseases other than hereditary hemochromatosis.

Current gastroenterology reports - 1 Jan 1999

Bonkovsky H L, Obando J V

Abstract excerpt

Heavy iron overload, as occurs in primary and secondary hemochromatosis, may cause fibrosis of parenchymal organs, including the heart, liver, and pancreas, and it is a risk factor for the development of hepatocellular carcinoma. Recent evidence indicates that lesser degrees of hepatic iron deposition are also risk factors for nonhemochromatotic liver disease. For example, several recent studies showed...

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Topics

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Share to Hemochromatosis
Share to Hemochromatosis Protein
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA Antigens

Share to Iron Overload

Share to Liver Cirrhosis

Share to Liver Diseases

Share to Mutation, Missense

Source

Identifiers

PMID: 10980924
DOI: 10.1007/s11894-999-0084-5

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Role of HFE gene mutations in liver diseases other than hereditary hemochromatosis.PMID 10980924Read ↗

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Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment.Semantic proximity Read ↗

Review article: the genetic basis of haemochromatosis.Semantic proximity Read ↗

Prevalence and clinical significance of HFE gene mutations in patients with iron overload.Semantic proximity Read ↗

Hereditary hemochromatosis.Semantic proximity Read ↗

Possible roles of the hereditary hemochromatosis protein, HFE, in regulating cellular iron homeostasis.Semantic proximity Read ↗

Pathophysiological consequences and benefits of HFE mutations: 20 years of research.Semantic proximity Read ↗

Pathogenesis, Diagnosis and Treatment of Hemochromatosis.Semantic proximity Read ↗

Hereditary hemochromatosis: insights from the Hemochromatosis and Iron Overload Screening (HEIRS) Study.Semantic proximity Read ↗

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