Article
Iron as a co-morbid factor in nonhemochromatotic liver disease.
Alcohol (Fayetteville, N.Y.) - 1 Jun 2003
Bonkovsky Herbert L, Lambrecht Richard W, Shan Ying
Abstract excerpt
Heavy iron overload, in both primary and secondary hemochromatosis, may cause fibrosis of parenchymal organs, especially the liver. The toxicity of iron is believed to involve increased oxidative stress, with iron-catalyzed production of reactive oxygen species causing oxidative damage to lipids, proteins, and nucleic acids. Lesser degrees of hepatic iron deposition are also associated with, and seem to be risk...
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