Molecular Epidemiology of<i>nga</i>and NAD Glycohydrolase/ADP‐Ribosyltransferase Activity among<i>Streptococcus pyogenes</i>Causing Streptococcal Toxic Shock Syndrome

Abstract excerpt

Severe invasive group A streptococcal (GAS) infections emerged in the late 1980s, yet no single virulence factor has been common to all isolates from infected patients. A strong association was recently found between isolates of such cases (regardless of M type) and the production of NAD glycohydrolase (NADase). Of interest, all M-1 strains isolated after 1988 were positive for NADase, whereas virtually all M-1...

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