Article
Comparison study for identifying promoter allelic polymorphism in interleukin 10 and tumor necrosis factor alpha genes.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Sept 2000
Agarwal P, Oldenburg M C, Czarneski J E, Morse R M, Hameed M R, Cohen S, Fernandes H
Abstract excerpt
Cytokines such as tumor necrosis factor (TNF)-alpha and Interleukin (IL)-10 play significant roles in autoimmunity and transplantation tolerance. Allelic polymorphisms that occur in the regulatory regions of these cytokine genes are closely associated with acute and chronic transplant rejection. The presence of a G-to-A polymorphism at position -308 in the promoter region of the TNF-alpha gene can increase...
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