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Article

Resistance to thyroid hormone in a family with no TRbeta gene anomaly: pathogenic hypotheses.

Annales d'endocrinologie - 1 Sept 2000

Vlaeminck-Guillem V, Margotat A, Torresani J, D'herbomez M, Decoulx M, Wémeau J L

Abstract excerpt

UNLABELLED: Syndromes of resistance to thyroid hormone (RTH) are almost always linked to a defective triiodothyronine-receptor B gene (TRB). Only six families with RTH exhibiting a normal TRB gene have been reported so far. We report another and discuss possible mechanisms. PATIENTS AND METHODS: We studied a kindred expressing a typical RTH phenotype. DNA was amplified and the TRB gene was sequenced. Linkage...

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Source

Identifiers

PMID: 10970943

Genes

TRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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