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Article

Inactivation of retinoblastoma protein in uveal melanoma by phosphorylation of sites in the COOH-terminal region.

Cancer research - 15 Aug 2000

Brantley M A, Harbour J W

Abstract excerpt

Uveal melanoma is the most common malignancy of the eye, but little is known about its underlying genetic defects. Melanomas of uveal origin, unlike those of the skin, are rarely familial and have not been linked consistently to mutations in tumor suppressor genes. Here, we investigated the Rb pathway in uveal melanoma. Most tumors displayed strong immunostaining for Rb and p16, suggesting that they were not...

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Identifiers

PMID: 10969768
PMCID: PMC5395201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Inactivation of retinoblastoma protein in uveal melanoma by phosphorylation of sites in the COOH-terminal region.PMID 10969768Read ↗

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A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.Semantic proximity Read ↗

A cyclin D1/cyclin-dependent kinase 4 binding site within the C domain of the retinoblastoma protein.Semantic proximity Read ↗

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