Article
L-MYC and GSTM1 polymorphisms are associated with unfavourable clinical parameters of gliomas.
Journal of experimental & clinical cancer research : CR - 1 Jun 2000
Kondratieva T V, Imyanitov E N, Togo A V, Zaitseva O A, Yatsuk O S, Romanenko S M, Bersnev V P, Hanson K P
Abstract excerpt
L-MYC and GSTM1 genotypes were analysed in glioma patients (GP) and healthy donors (HD). None of these genes appeared to influence the risk of this disease, however both polymorphisms correlated with unfavourable clinical parameters of gliomas. In particular, S allele of the L-MYC was overrepresented in the relapsed patients (P < 0.05), and GSTM1-null genotype was associated with the advanced tumour grade (P <...
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