Article
N(G)-monomethyl-L-arginine inhibits erythropoietin gene expression by stimulating GATA-2.
Blood - 1 Sept 2000
Tarumoto T, Imagawa S, Ohmine K, Nagai T, Higuchi M, Imai N, Suzuki N, Yamamoto M, Ozawa K
Abstract excerpt
N(G)-monomethyl-L-arginine (L-NMMA) has been reported to be elevated in uremic patients. Based on the hypothesis that the pathogenesis of the anemia of renal disease might be due to the perturbation of transcription factors of the erythropoietin (Epo) gene by L-NMMA, the present study was designed to investigate the effect of L-NMMA on Epo gene expression through the GATA transcription factor. L-NMMA caused...
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