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Article

Gene structure of the human receptor tyrosine kinaseRON and mutation analysis in lung cancer samples

1 Jan 2000

Abstract excerpt

The human RON gene (MST1R) maps to 3p21.3, a region frequently altered in lung cancer and other malignancies. It encodes a receptor tyrosine kinase (RTK) closely related to MET, whose mutations are associated with neoplasia. We investigated whether RON might be involved in the development or progression of lung cancer. We first determined the exon-intron structure of the gene by direct sequencing of RON cosmid...

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PMID: 10959094
DOI: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1015>3.0.co;2-n

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