Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A role for carnosine in cellular maintenance.

Biochemistry. Biokhimiia - 1 Jul 2000

Holliday R, McFarland G A

Abstract excerpt

The dipeptide L-carnosine has beneficial effects on cultured human fibroblasts. Physiological concentrations in standard media prolong their in vitro lifespan and strongly reduce the normal features of senescence. Late passage cells in normal medium are rejuvenated when transferred to medium containing carnosine, and become senescent when carnosine is removed. In the absence of pyruvate, carnosine is cytotoxic to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Cell Division
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Survival

Share to Cellular Senescence

Share to Culture Media

Share to Fibroblasts

Share to Phenotype

Source

Identifiers

PMID: 10951103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

A role for carnosine in cellular maintenance.PMID 10951103Read ↗

l-Carnosine reduces telomere damage and shortening rate in cultured normal fibroblastsSemantic proximity Read ↗

Retardation of the Senescence of Cultured Human Diploid Fibroblasts by CarnosineSemantic proximity Read ↗

L-carnosine affects the growth of Saccharomyces cerevisiae in a metabolism-dependent manner.Semantic proximity Read ↗

Further evidence for the rejuvenating effects of the dipeptide l-carnosine on cultured human diploid fibroblastsSemantic proximity Read ↗

L-carnitine Effectively Induces<i>hTERT</i>Gene Expression of Human Adipose Tissue-derived Mesenchymal Stem Cells Obtained from the Aged SubjectsSemantic proximity Read ↗

Cellular senescence: a reflection of normal growth control, differentiation, or aging?Semantic proximity Read ↗

Anti-aging protective effect of L-carnitine as clinical agent in regenerative medicine through increasing telomerase activity and change in the hTERT promoter CpG island methylation status of adipose tissue-derived mesenchymal stem cellsSemantic proximity Read ↗

Targeting metabolism in cellular senescence, a role for intervention.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.