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Article

The "comparative growth assay": examining the interplay of anti-cancer agents with cells carrying single gene alterations.

Neoplasia (New York, N.Y.) - 1 Oct 1999

Hausner P, Venzon D J, Grogan L, Kirsch I R

Abstract excerpt

We have developed a "comparative growth assay" that complements current assays of drug effects based on cytotoxicity. A co-culture of two cell lines, one of which is fluorescently labeled, is exposed to a cytotoxic agent and the proportion of fluorescent cells is compared with that of a baseline unexposed co-culture. For demonstration purposes, two HCT116 cell lines (an hMLH1 homozygous and an hMLH1 heterozygous...

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Identifiers

PMID: 10935491
DOI: 10.1038/sj.neo.7900047
PMCID: PMC1508098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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