Article
Genetic variations of the midkine (MK) gene in human sporadic colorectal and gastric cancers.
International journal of molecular medicine - 1 Sept 2000
Ahmed K M, Shitara Y, Kuwano H, Takenoshita S, Uchimuro K, Shinozawa T
Abstract excerpt
Midkine (MK), a retinoic acid responsible protein, is regulated during development and may play an important role in tumorigenesis. A search for genetic variations of the MK gene, located on chromosome 11q11.2 in humans, has not yet been conducted in cancers. To examine the entire coding region, as well as 4 regions of the promoter covering all functional motifs, 8 sets of intron-based and promoter region primers...
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