Article
Distinction between coeliac disease and refractory sprue: a simple immunohistochemical method.
Histopathology - 1 Jul 2000
Patey-Mariaud De Serre N, Cellier C, Jabri B, Delabesse E, Verkarre V, Roche B, Lavergne A, Brière J, Mauvieux L, Leborgne M, Barbier J P, Modigliani R, Matuchansky C, MacIntyre E, Cerf-Bensussan N, Brousse N
Abstract excerpt
AIMS: We recently showed that refractory sprue is distinct from coeliac disease, the former being characterized by abnormal intraepithelial T-lymphocytes expressing a cytoplasmic CD3 chain (CD3c), lacking CD3 and CD8 surface expression, and showing TCRgamma gene rearrangements. To take advantage of the abnormal phenotype of CD3c + CD8 - intraepithelial lymphocytes (IEL) in refractory sprue we developed a simple...
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