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Article

Mucosal Intraepithelial T-lymphocytes in Refractory Celiac Disease: A Neoplastic Population With a Variable CD8 Phenotype

1 May 2008

Abstract excerpt

Celiac disease (CD) is characterized by villous atrophy and an increase in intraepithelial lymphocytes (IEL). The IEL usually exhibit a suppressor/cytotoxic phenotype (CD3 and CD8) and display a polyclonal profile for T-cell receptor (TCR) rearrangement as opposed to the monoclonality of refractory CD (RCD) with CD8 IEL. A complication of CD is the loss of response to a gluten-free diet called RCD that may...

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PMID: 18360280
DOI: 10.1097/pas.0b013e318159b478

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