Article
High-producer haplotypes of tumor necrosis factor alpha and lymphotoxin alpha are associated with an increased risk of myeloma and have an improved progression-free survival after treatment.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Aug 2000
Davies F E, Rollinson S J, Rawstron A C, Roman E, Richards S, Drayson M, Child J A, Morgan G J
Abstract excerpt
PURPOSE: To determine the effect of polymorphic variations in the tumor necrosis factor alpha (TNFalpha) and lymphotoxin alpha (LTalpha) genes on the predisposition to myeloma and the effect of these polymorphisms on response to treatment and overall survival. PATIENTS AND METHODS: Genotype distribution was determined in 63 patients with monoclonal gammopathy of uncertain significance (MGUS) and 198 patients with...
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