Article
The molecular defect in hypotransferrinemic mice.
Blood - 1 Aug 2000
Trenor C C, Campagna D R, Sellers V M, Andrews N C, Fleming M D
Abstract excerpt
Hypotransferrinemic (Trf(hpx/hpx)) mice have a severe deficiency in serum transferrin (Trf) as the result of a spontaneous mutation linked to the murine Trf locus. They are born alive, but before weaning, die from severe anemia if they are not treated with exogenous Trf or red blood cell transfusions. We have determined the molecular basis of the hpx mutation. It results from a single point mutation, which alters...
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