Article
Tumor gene therapy by MVA-mediated expression of T-cell-stimulating antibodies.
Cancer gene therapy - 1 May 2002
Paul Stephane, Regulier Etienne, Rooke Ronald, Stoeckel Fabienne, Geist Michel, Homann Horst, Balloul Jean-Marc, Villeval Dominique, Poitevin Yves, Kieny Marie-Paule, Acres R Bruce
Abstract excerpt
Immune responses to tumor-associated antigens are often dampened by a tumor-induced state of immune anergy. Previous work has attempted to overcome tumor-induced T-cell anergy by the direct injection of vectors carrying the genes encoding one of a variety of cytokines. We hypothesised that the polyclonal stimulation of T cells, preferably through the TCR complex, would result in a cascade of cytokines associated...
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