Article
Selective assembly and remodelling of collagens II and IX associated with expression of the chondrocyte hypertrophic phenotype.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2000
Mwale F, Billinghurst C, Wu W, Alini M, Webber C, Reiner A, Ionescu M, Poole J, Poole A R
Abstract excerpt
The assembly and resorption of the extracellular matrix in the physis of the growth plate are poorly understood. By examining isolated fetal growth plate chondrocytes in culture and using immunochemical methods we show that type II collagen, proteoglycan aggrecan, and type IX collagen are assembled into a matrix that is initially enriched in type II collagen over proteoglycan and type IX collagen. When compared...
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