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Article

Tumor microenvironment: The role of the tumor stroma in cancer

16 Jan 2007

Abstract excerpt

The tumor microenvironment, composed of non-cancer cells and their stroma, has become recognized as a major factor influencing the growth of cancer. The microenvironment has been implicated in the regulation of cell growth, determining metastatic potential and possibly determining location of metastatic disease, and impacting the outcome of therapy. While the stromal cells are not malignant per se, their role in...

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PMID: 17226777
DOI: 10.1002/jcb.21159

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