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Article

The Helicobacter pylori pyrB gene encoding aspartate carbamoyltransferase is essential for bacterial survival.

Archives of biochemistry and biophysics - 1 Aug 2000

Burns B P, Hazell S L, Mendz G L, Kolesnikow T, Tillet D, Neilan B A

Abstract excerpt

The production of defined isogenic Helicobacter pylori pyrB mutants was undertaken to investigate the role of aspartate carbamoyltransferase (encoded by pyrB) in the survival of the bacterium. The complete structural gene for aspartate carbamoyltransferase from H. pylori strain RU1 was cloned into Escherichia coli by complementation of a pyrB auxotrophic mutant to facilitate the construction of a pyrB-disrupted...

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Share to Aspartate Carbamoyltransferase
Share to Chloramphenicol O-Acetyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Genetic Complementation Test

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Share to Transformation, Genetic

Source

Identifiers

PMID: 10900135
DOI: 10.1006/abbi.2000.1920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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