Article
Lack of genetic linkage or association between a functional serotonin transporter polymorphism and panic disorder.
Psychiatric genetics - 1 Mar 1999
Hamilton S P, Heiman G A, Haghighi F, Mick S, Klein D F, Hodge S E, Weissman M M, Fyer A J, Knowles J A
Abstract excerpt
Given the efficacy of medications that interact with the serotonin transporter (5-HTT) in the treatment of panic disorder, we have used a family-based design to test for genetic association and linkage between panic disorder and a functional polymorphism in the promoter of the gene for 5-HTT. In this study, 340 individuals in 45 families, as well as 74 haplotype relative risk 'trios' were genotyped at the...
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