Article
Breast cancer, passive and active cigarette smoking and N-acetyltransferase 2 genotype.
Pharmacogenetics - 1 Jul 2000
Delfino R J, Smith C, West J G, Lin H J, White E, Liao S Y, Gim J S, Ma H L, Butler J, Anton-Culver H
Abstract excerpt
The relationship of breast cancer to cigarette smoking is inconsistent in the literature, possibly due in part to heterogeneity in carcinogen metabolism. N-acetyltransferase 2 (NAT2) enzyme activity is believed to play a role in the activation of tobacco smoke carcinogens. We examined the effect of NAT2 genetic polymorphisms on risk of breast cancer from active and passive smoking. Women were recruited from those...
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