Article
Association and linkage studies of CRH and PENK genes in bipolar disorder: a collaborative IGSLI study.
American journal of medical genetics - 3 Apr 2000
Alda M, Turecki G, Grof P, Cavazzoni P, Duffy A, Grof E, Ahrens B, Berghöfer A, Müller-Oerlinghausen B, Dvoráková M, Libigerová E, Vojtĕchovský M, Zvolský P, Joober R, Nilsson A, Prochazka H, Licht R W, Rasmussen N A, Schou M, Vestergaard P, Holzinger A, Schumann C, Thau K, Rouleau G A
Abstract excerpt
Corticotropin-releasing hormone (CRH) and proenkephalin (PENK) are hypothalamic peptides involved in the stress response and hypothalamic-pituitary axis regulation. Previous research has implicated these peptides in the pathogenesis of affective disorders. In this study we investigated two polymorphisms located in the genes that code for CRH and PENK by means of association and linkage analyses. A total of 138...
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