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Article

Lack of association between a functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene and tardive dyskinesia in schizophrenia.

American journal of medical genetics - 8 Aug 2001

Schulze T G, Schumacher J, Müller D J, Krauss H, Alfter D, Maroldt A, Ahle G, Maroldt A O, Novo y Fernández A, Weber T, Held T, Propping P, Maier W, Nöthen M M, Rietschel M

Abstract excerpt

Tardive dyskinesia (TD) is a common side effect of long-term medication with typical neuroleptics. TD presents itself by abnormal involuntary movements and may lead to a potentially disabling and chronic clinical course. A vast majority of patients suffering from schizophrenia are smokers. Smoking has been reported to induce the activity of the CYP1A2 enzyme, which is an established metabolic pathway within the...

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Identifiers

PMID: 11496364
DOI: 10.1002/ajmg.1472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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